Anatomic pathology

The research activities in this area are:

Pathophysiology of organ transplants

Vascular allografts (Tissue Bank)

Pre-transplant phase. Quality control of the tissue: investigation of possible inflammatory tissue and "dystrophic" abnormalities, in order to identify any immunomorphological factors which might predict the lifespan of the vascular allograft.

Post-transplant phase.Checking the state of preservation of the tissue. Study of acute and chronic rejection of the vascular segment, depending on the time elapsed and the morphological characteristics that caused the transplant to fail; correlations with the pre-transplant data.

Kidney transplant

Pre-transplant phase. A physiopathological approach to the evaluation of the kidney before the transplant: assessment of glomerular and arterial degeneration/inflammation and the inflammatory and autoantibody component, as well as their impact on the pre-transplant score (Karpinsky score) which is currently used to pathologically assess the organ before transplantation.

Liver neoplasms and liver transplantation (OLT)

Pre-transplant phase. Assessment of the neoangiogenesis and growth patterns of neovessels in the lesions occupying space in the liver, both benign (hepatocellular adenomas, inflammatory adenomas, and focal nodular hyperplasia) and malignant (hepatocellular carcinomas). The diagnostic/prognostic significance of neoangiogenesis: the risk of hepatocellular carcinoma from multiple adenomas, for the purpose of the OLT.



Hematopathology

Pathobiology of peripheral T cell lymphomas

Peripheral T cell lymphomas represent an orphan disease, due not only to their relative rarity (12-15% of total lymphatic tissue tumors), but also to the lack of biopathological knowledge, which is reflected in the poor clinical-therapeutic results. The most common results category, "peripheral T lymphoma not otherwise specified", no doubt conceals a Pandora’s box. Through the use of high-definition technologies (gene expression profile, microRNA profile, SNP array, methylation, acetylation, RNA sequencing, massive genome sequencing), as well as in vitro and in vivo models, new categories of cancer will be defined, histogenetic and pathogenetic mechanisms will be revealed, and targets for highly effective personalized treatment will be identified. An additional research objective is the creation of molecular diagnostic tools which can be used by pathologists without experienced in thi field, enabling them to arrive at a correct, reproducible interpretation of the process.

Blastic neoplasia derived from dendritic plasmocytoid cells

The rationale and modality of this study are similar to those for peripheral T cell lymphomas explained above.

Burkitt’s lymphoma

The project is supported by PRIN-COFIN, FIRB, and BolognAIL funds.

The aim is to define the biomolecular characteristics of endemic, sporadic, and HIV-related forms.

Hodgkin’s lymphoma

The project is supported by a BolognAIL grant. The objective of the research is to define the prognostic predictive factors which will allow us to identify patients who will develop rapid chemo-resistance or early relapse, who make up about 30% of those with Hodgkin’s lymphoma. These patients are currently only partially recognized by PET after two cycles of ABVD—that is to say to after therapy has already started, at which point clonal selection and chemo-resistance phenomena are already occurring.

Typing of neoplasms of the hemolymphopoetic system for prognostic-therapeutic purposes

The project, supported by institutional funds and the Fondazione Italiana Linfomi (FIL), applies to every type of cancer in the specific sector, such as chronic lymphatic leukemia. The research also includes the determination of the minimum residual post-therapy disease.

People

Lisa Argnani

Senior assistant professor (fixed-term)

keywords: Lymphomas

Antonio De Leo

Junior assistant professor (fixed-term)

keywords: Molecular Pathology, Endocrine Pathology, Gynecologic Pathology, Molecular Oncology, Molecular Diagnostics, Adrenal
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Antonietta D'Errico

Full Professor

keywords: Liver transplantation, Intestinal transplantation, HCV infection, Molecular monitoring of rejection, therapeutic
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Emi Dika

Associate Professor

keywords: mohs surgery, melanoma
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Paola Feraco

PhD Student

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Michelangelo Fiorentino

Associate Professor

keywords: Molecular Pathology, Genito-Urinary Pathology
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Cinzia Girone

PhD Student

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Pier Luigi Lollini

Full Professor

keywords: Vaccines, Oncology, Cancer research, Transgenic mice, Tumor immunology, Cancer prevention

Maria Abbondanza Pantaleo

Associate Professor

keywords: Rare tumors, Gastrointestinal stromal tumors (GIST) and sarcoma, Predictive factors, Next Generation Sequencing of
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Piero Parchi

Associate Professor

keywords: Human prion diseases, Protein chemistry, Neuropathology, Neurodegeneration, Proteomic, Biomarkers in Neurology, Rapidly
keywords: adult mesenchymal stem cells, endothelial progenitors, angiogenesis, vascular wall, vascular injury, electron
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Pier Paolo Piccaluga

Associate Professor

keywords: dermatology

Alessia Sonetto

PhD Student

Giovanni Tallini

Full Professor

keywords: anatomic pathology, surgical pathology, cytopathology, molecular diagnostics, molecular pathology, molecular pathology