Urology

Research activities

Cryoablation (CA) and Percutaneous Radiofrequency Ablation (RFA) of small renal masses: oncological and functional results compared to conservative renal surgery

Radio-guided Robotic Surgery with 99mTc-PSMA and DROP-IN gamma probe for lymph node metastases in patients with high-risk prostate cancer

3D imaging with augmented reality and artificial intelligence for surgical navigation during radical prostatectomy and robotic partial nephrectomy

Application of 3D technology and augmented reality in the study of the vascular tree during removal from living donors in robotic surgery

Use of HIFU technology to treat low- and intermediate-risk prostate cancer

Metastasis rescue therapy guided by PET/CT with PSMA in patients with prostate cancer recurring after primary treatment

Development of nephrometric scores with 3D technology parameters to define the complexity of kidney tumors and predict surgical complications

Robotic radical cystectomy with intracorporeal urinary diversion in patients with high-risk bladder cancer: comparison of perioperative, oncological, and functional outcomes compared to the open technique

Use of new robotic platforms for urological surgery: feasibility, safety, and cost analysis in radical prostatectomy, partial nephrectomy, and robotic pyeloplasty compared to the DaVinci system

Research projects

  1. Prospective study for evaluation of oncological and functional outcomes of the application of robotic technology for radical cystectomy interventions with intracorporeal urinary diversion for bladder cancer
  2. Application of percutaneous ablative therapies with radiofrequency and cryoablation in patients diagnosed with renal cancer who are not eligible for surgery
  3. Application of virtual 3D models for the anatomical study of renal neoplasms and re-evaluation of nephrometric scores to improve the functional outcomes of partial nephrectomy in patients with renal cancer who are candidates for conservative renal surgery
  4. Application of 3D models for preoperative planning of percutaneous ablative treatments of small renal masses
  5. Development of dedicated nephrometric scores with 3D technology parameters to define the complexity of renal tumors and predict the outcome of conservative kidney surgery
  6. Observational study of active surveillance and early radiotherapy intervention in patients undergoing radical prostatectomy for prostatic neoplasms at high risk of recurrence (EASY-1)
  7. Prospective study to develop augmented reality technology of 3D models to guide the intervention of robotic radical prostatectomy and allow the positive surgical margins to be reduced, by real-time histological examination at the level of the index lesion
  8. Prospective study to develop augmented reality technology of 3D models to guide robotic partial nephrectomy and allow greater use of selective arterial clamping and better surgical outcomes
  9. Development of automatic system in robotic surgery for partial nephrectomies and radical prostatectomies which pairs 3D models with augmented reality technology through computer vision method processing (Collaboration with Laboratorio di Bioingegneria Prof.ssa Marcelli)
  10. Development of software to predict the effectiveness of simulated selective arterial clampings on 3D models (Collaboration with Bioengineering Laboratory Prof.ssa Marcelli)
  11. Prospective study to develop artificial intelligence technology applied to augmented reality of 3D models, to guide the intervention of radical robotic prostatectomy (with Intuitive grant of $60,000)
  12. Prospective study to evaluate radical (surgical or radiotherapy) treatment of primary prostate cancer associated with multimodal systemic therapy in patients with oligometastatic prostate cancer
  13. External nomogram validation to predict the positive result of PET PSMA in patients with prostate cancer with biochemical recurrence
  14. Retrospective and prospective multicenter study to define the impact of PET-PSMA on intention to treat in patients with biochemical recurrence after radical prostatectomy for prostate cancer and the impact of PSMA guided target therapies on long-term oncology outcomes (Collaboration with Aalst Prof. Mottrie, IRCCS San Raffaele Prof. Briganti, Medicina Nucleare Prof. Fanti, IEO Dr. Ceci)
  15. Multicentric study to evaluate the intention to treat, and the effectiveness of PSMA guided therapies, in patients with PSA persistence after radical prostatectomy (in collaboration with IRCCS San Raffaele Prof. Briganti, Nuclear Medicine Prof. Fanti)
  16. Prospective study to evaluate the intention to treat and the effectiveness of preoperative staging with PET PSMA in patients with high-risk prostate cancer (in collaboration with Nuclear Medicine Prof. Fanti)
  17. Prospective study to assess the effectiveness of radio-guided surgery (PSMA-guided lymphadenectomy) using 99Tc-tracerPSMA and gamma drop probe in robotic surgery, both in high-risk patients to improve the pelvic lymphadenectomy template during robotic radical prostatectomy and in patients with biochemical recurrence after radical treatment and oligometastatic lymph node recurrence to improve the effectiveness of robotic rescue lymphadenectomy (in collaboration with Medicina Nucleare Prof. Fanti, Dr. Castellucci, D. Farolfi)
  18. Prospective study to evaluate the effectiveness of preoperative prophylaxis with phosphomycin in patients suffering from prostate hypertrophy undergoing deconstructive surgery (TURP and HoLEP)
  19. Participation in a multicentric, international, and observational study to evaluate serum and urinary glycosaminoglycans as predictors of clinical recurrence in patients undergoing surgery who have clear cell renal neoplasia with Leibovich score ≥5 (AUR87A study)
  20. Impact of multi-parameter magnetic resonance to assess muscle infiltration in patients with first diagnosis of bladder cancer (VIRADS multicenter study)
  21. NIAGARA prospective randomized study to evaluate oncological outcomes in patients diagnosed with invasive muscle bladder neoplasm, comparing neoadjuvant chemotherapy to immunotherapy + neoadjuvant chemotherapy before radical cystectomy
  22. Prospective study to evaluate the detection rate of FUSION-targeted prostate biopsies for the diagnosis of clinically significant prostate neoplasms
  23. Retrospective study to assess the impact of ADC parameters of the multiparametric magnetic resonance lesion index on predictions of the presence of clinically significant prostate cancer during FUSION-targeted prostate biopsies and after radical prostatectomy (collaboration with Radiology, Dr C. Gaudiano, Dr. B. Corcioni, and Prof. R. Golfieri)
  24. Retrospective study to assess the impact of ADC parameters of multiparametric MRI on predictions of the presence of prostate cancer with cribriform patterns in FUSION-targeted prostate biopsies and in radical prostatectomy specimens (collaboration with Radiology, Dr C. Gaudiano, Dr. B. Corcioni and Prof.ssa R. Golfieri)
  25. Impact of the experience of a dedicated radiological and uroradiological reference center in the diagnosis of clinically significant prostate cancer through multiparametric magnetic resonance
  26. Impact of concurrent prostate mapping at the same site as FUSION-targeted sampling during prostate biopsy in patients with suspected clinical prostate cancer
  27. Multicentric and international prospective and retrospective study to evaluate oncological and functional outcomes of retroperitoneal lymphadenectomy, for testicular neoplasms with retroperitoneal metastases in a primary setting as well as those with a residual retroperitoneal mass after chemotherapy, compared to the open, laparoscopic, and robotics technique (In collaboration with Istituto Italiano dei Tumori Prof. Salvioni and Prof. Nicolai and the Swedish center of Seattle Prof. Porter)
  28. Prospective interventional study to evaluate the oncological outcomes of focal treatments with ultrasound energy (HIFU) for the treatment of prostate neoplasms at low and intermediate risk
  29. Retrospective multicentric study to evaluate oncological and functional outcomes and define predictors of treatment success and relapses, dedicated renal scores to evaluate renal mass complexity, and dedicated follow-up protocols in patients undergoing percutaneous ablative treatments for small renal mass (project sponsored by the Imaging group of the Italian Society of Urology, in collaboration with IEO Prof. De Cobelli, Dr. Musi, and Dr. Luzzago and with IRCCS San Raffaele Prof. Montorsi, Prof. Gallina, and Dr. Bandini)
  30. Multicenter, multinational observational study for the assessment of oncological and functional outcomes of patients with renal cancer undergoing multiple treatments, including active surveillance, percutaneous or surgical ablative treatment, and systemic therapy (iRECORD)
  31. Observational study of the urethral pressor profile during the individual steps of the robotic radical prostatectomy performed on patients suffering from prostate cancer, to assess the impact of each step on the values of the urethral profile at the level of the sphincter complex and to evaluate predictors of early recovery of urinary continence (Financing Fondazione Del Monte)
  32. Assessment of PSMA expression in surgical specimens from radical prostatectomy and pelvic lymphadenectomy by correlating imaging data (preoperative PET PSMA) with an immunohistochemistry evaluation of the surgical specimen for patients undergoing radical prostatectomy with pelvic lymphadenectomy for prostatic neoplasm and evidence of metastatic lymph nodes in the definitive histological examination (Collaboration with Nuclear Medicine Prof. Fanti, Dr. Castellucci, Dr. Farolfi, and Dr Mei and Pathological Anatomy Prof. Fiorentino and Dr. Giunchi)
  33. Impact of innovative and ultra-minimally invasive endoscopic therapies for the treatment of benign prostatic hypertrophy (Aquabeam with water dissection and Rezum with water vapor vaporization)

People

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Eugenio Brunocilla

Full Professor

keywords: Urology; Robotic Surgery; Urolithiasis; Oncologic Surgery; Urinary Reconstructive Surgery
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Francesco Chessa

PhD Student

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Michelangelo Fiorentino

Associate Professor

keywords: Molecular Pathology, Genito-Urinary Pathology
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Francesco Massari

Senior assistant professor (fixed-term)

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Riccardo Schiavina

Full Professor

keywords: robotic surgery, Prostate cancer, micrometastases, PET/CT, imaging, Lymph-nodes, Kidney cancer, laser (Holep),