Allogenic transplantation of hematopeic stem cells and advanced cell-based therapies

Clinical and biological research in the area of allogenic transplantation of hematopeic stem cells (GVHD, complications) and advanced cell-based therapies, such as CAR-T (predictive biomarkers for complications from cell-based therapies, new organizational models for the healthcare system)

Research area:

Clinical and biological research in the area of allogenic transplantation of hematopeic stem cells

 

Research projects:

Biological projects

  1.  Role of inflammatory DNA, nanovesicles, miRNA, and methylation in allogenic transplants of hemopoetic stem cells
  2. Role of inflammatory DNA, nanovesicles, miRNA, and methylation in predicting complications after CAR-T cellular infusions
  3. Cytoflorometric and molecular tracking of infused CAR-T cells

Clinical projects

  1. Impact of age in the outcome of allogenic transplantation of hematopeic stem cells
  2. Role of transplants in acute leukemia
  3. Prophylaxis and treatment of GVHD with biologic drugs (e.g., ATLG) and cell-based therapies
  4. Use of T-reg cells for the treatment of chronic GVHD

 

Ongoing research objectives:

  1. Extended patient sampling for the biological studies
  2. Development of cytoflorometric and molecular tracking of infused CAR-T cells
  3. Optimization of the isolation of nanovesicles
  4. Multicentric, retrospective study of allogenic transplantation of hematopeic stem cells in the elderly
  5. Multicentric, prospective study of allogenic transplantation in patients with acute, active leukemia
  6. Pharmacokinetics and molecular signatures of patients who have undergone allogenic transplantation of hematopeic stem cells after receiving polyclonal, anti-lymphocytic serum

Principal investigator

Team

Mario Arpinati

Adjunct professor

Enrica Tomassini

Research fellow

Collaborators

Clinical group

Mario Arpinati, professore a contratto

Michele Dicataldo, specializzando

Francesco Barbato

Biological group

Storci Gianluca

Serena De Matteis

Noemi Laprovitera

Other collaborators

Manuela Ferracin, professoressa associata, DIMES

Paolo Garagnani, professore associato, DIMES