Research groups

  • Alopecia

    The Emotional Regulation and the Quality of Life of Patients with Alopecia: Observational prospective exploratory study

  • Environmental Health: Study of Environmental Carcinogens

    The research is focused on the study of 1) the causal relationships between environmental exposure to physical, chemical, and biochemical agents and health outcomes, in particular tumors of environmental origin and 2) the identification of the molecular and cellular events correlated with the process of carcinogenesis and with the definition of biological plausibility.

  • Genomic and post-genomic analysis of human chromosome 21 in trisomy 21 (Down syndrome)

    Our research group aims to systematically study the genetic mechanisms underlying Down syndrome and thus identify possible new therapeutic approaches.

  • Application and comparison of invasive and non-invasive methodologies in the study of diseases of the cutaneous annexes

    The purpose of the study is to evaluate the diagnostic accuracy of non-invasive instrumental methodologies—in particular OCT (optical coherence tomography) and confocal microscopy—in diseases of the cutaneous annexes and compare them to invasive methodologies (biopsy and surgical removal).

  • Research group in Audiology and Balance

    The primary objective of this Research Group is to investigate current issues in the field of high-incidence cochleo-vestibular diseases (benign paroxymal positional vertigo, dehiscence of the superior semicircular canal, Meniere's disease, hearing loss in infants and children, tinnitus, etc.). Most of the research activity is aimed at the development of innovative diagnostic and instrumental procedures.

  • Tumor Cell Biology

    The group's principal research activity is the study of the metabolic characteristics of tumor cells, particularly with respect to glucose metabolism. The scope of our work is evaluating how the metabolic axis of tumor cells can affect their phenotype as well as their response to pharmacological treatment.

  • Biomarkers of Aging and Age-Related Diseases

    How can we live longer and healthier? Biomarkers, including microRNAs (circulating or in organs/tissues), can help us answer this question, as they are regulators of gene expression and markers of pathologies, such as those associated with age.

  • Biotechnology of human stem cells

    The isolation and immuno-functional characterization of mesenchymal and epithelial stem cells, from adult and peri-natal tissues.

  • Stem Cells: Natural stimuli and physical energy to modulate the biology of human mesenchymal stem cells

    The aim of the research is to identify natural molecules and physical energy able to modulate the stemness, differentiation, and senescence of human stem cells.

  • Research group for Cervical-endocrine surgery

    This research group is dedicated to the surgical treatment of thyroid and parathyroid diseases (benign and malignant). The team collaborates with endocrinologists for a multidisciplinary management of these patients. Research activities are mainly aimed at the treatment of thyroid carcinomas, the role of intraoperative parathyroid hormone dosage in patients with hyperparathyroidism undergoing surgery, and methods for reducing the rate of complications—in particular, the use of laryngeal nerve-monitoring systems.

  • Research group for Head and Neck Cancer Surgery

    This research group is dedicated to the research of modern multidisciplinary treatment modalities for head and neck tumors. Prof. Presutti has solid experience in this field, having performed more than 15,000 cancer surgeries. The collaboration between surgeons, oncologists, radiotherapists, radiologists, and rehabilitation and palliative care teams adds further value to the group's multidisciplinary research activity. The efforts of our team are aimed at developing personalized treatments for the patient and applying minimally invasive surgical approaches and modern treatment methods, while seeking inclusion in experimental protocols.

  • Clinic of Pediatric Dermatology and Rare Diseases

    Diagnostic classification and treatment of dermatological pathologies in patients from neonatal age through adolescence;center of reference for Rare Diseases with cutaneous engagement in both child and adult populations.

  • SSD Diagnosis and Therapy of Lymphomas and Lymphoproliferative Syndromes

    There are currently approximately 100 clinical trials and innovative therapeutic programs promoted directly by SSD. We are the main player in the scientific research for the cure of lymphomas and lymphoproliferative syndromes, and in medicine personalized to the individual patient.

  • Non-invasive diagnostics and conservative therapy of periocular tumors

    Use of dermatoscopic diagnostic techniques for the early diagnosis and treatment of periocular neoplasms

  • Tissue degeneration and regeneration in the field of dentistry

    The study of inflammatory pathologies like periodontitis and peri-implantitis, which cause degeneration of the tissues supporting the teeth and dental implants, and the biomolecular and biomaterial treatments which can promote tissue regeneration.

  • Cellular differentiation and neoplastic transformation

    The study of the cell changes that drive neoplastic transformation and the development of oral and colo-rectal cancers.

  • Hemolymphopathology and Immunopathology

    a) The identification of new diagnostic and prognostic indicators, along with new therapeutic targets in neoplasias of the hematolymphoid system and b) The characterization of the populations and dynamics of the tumor micro-environment.

  • Toxic Enzymes and Immunotargeting

    The research group has many years of experience in the study of plant toxins with rRNA N-glycosylase activity, xanthine oxidoreductase, and pathogenic mechanisms of cellular intoxication, as well as in the implementation and analysis of immunoconjugates for specific drug targeting.

  • Functional genomics of complex human traits

    The main objective of the current project is the analysis of the function of individual gene units and their interactions with physiological and pathological cells, using approaches ranging from bioinformatics to organism modeling.

  • Glycobiology and glycopathology

    Study of the glycosyltransferases responsible for the biosynthesis of the sugar portions of glycoproteins and glycolipids, and of the role that alterations in these structures play in pathological processes such as cancer and congenital diseases of glycosylation.

  • Research group for organ transplant patients

    The objective of the research is to identify new screening and early diagnostic techniques for skin tumors in patients who have received organ transplants.

  • Immunology and biology of metastasis

    For over forty years, this research group has been involved in basic, translational, and preclinical oncological research on the molecular and cellular biology of cancer cells, tumor immunology, and the mechanisms of metastatic spread.

  • Histology and congenital diseases

    The study of the molecular alterations in various congenital diseases and in primary liver tumors, with particular interest in the prognostic and therapeutic aspects of hepatocarcinoma as well as in the morphological and functional changes that characterize the pathological processes themselves.

  • Primary lymphomas of the skin

    Cutaneous lymphomas are a heterogeneous group of T and B lymphoproliferative disorders with clinical, histological, and immunophenotypic characteristics. Although they are increasingly common, these malignancies are still rare (7 new diagnoses/million inhabitants/year). The group’s objective is to study new diagnostic approaches, predictive parameters, and innovative therapeutic approaches for this type of disease.

  • Sexually Transmitted Diseases (STDs) and neglected tegumentary infections

    Research group on emerging STIs and neglected infections of the skin, with a specific interest on tegumentary leishmaniosis.

  • Complex Diseases

    Applying the diagnostic techniques available today for the diagnosis, treatment, and follow-up of the principal inflammatory diseases of the skoin with the goal of improving patients’ prognosis and quality of life.

  • Molecular markers of bone sarcomas

    Identification of the genetic and molecular markers critical for osteosarcoma and Ewing sarcoma progression, which are also useful for the development of targeted, personalized therapies.

  • Molecular mechanisms shared between aging, age-associated diseases and human longevity

    We are a group of researchers coordinated by Prof. Stefano Salvioli interested in defining the shared molecular mechanisms between human aging and age-related diseases such as Type II Diabetes and Alzheimer's Disease.

  • Molecular and cellular mechanisms of oxidative stress

    The aim of the research activity is to study the role of oxygen and nitrogen radical species in physiological and pathological conditions in order to investigate the molecular mechanisms underlying the redox state alterations.

  • Regenerative cardiac medicine, cardiotoxicity, and differentiation therapies in oncology

    Our group is proposing new molecular strategies to protect and regenerate the heart after severe damage, by stimulating the survival and proliferation ofcardiac muscle cells. In the field of oncology, we are studying strategies to halt the cancer’s progression and spread by curbing cellular differentiation.

  • Multiple Myeloma (MM) Research Group

    The MM research group has two parts: a clinical component, largely involved in the treatment of patients at all stages of the disease and in clinical research activities through the promotion and conduct of national and international clinical trials; and a laboratory counterpart, dedicated to translational research in the field of molecular biology, with the support of a group of bio-informaticians.

  • Nephro-Vascular Pathology

    Our research group investigates the biology of vascular cells and the mechanisms involved in the pathogenesis of vascular and nephrological diseases, using cell and molecular biology techniques and morphological and electron microscopy approaches.

  • Ph1-negative chronic myeloproliferative neoplasms (MPN), immune thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (PTT)

    Clinical and laboratory research group, dedicated to the study and treatment of Ph1-negative chronic myeloproliferative neoplasms (MPN): myelofibrosis, polycythemia vera, and essential thrombocythemia; immune thrombocytopenic purpura (ITP); and Thrombotic Thrombocytopenic Purpura (PTT).The group’s research objective is to provide clinical assistence at the highest level, guaranteeing the many patients with MPN, ITP, or PTT the best therapies that the international scientific community can provide.

  • NET TEAM Bologna – ENETS Center of Excellence for the diagnosis and cure of neuroendocrine tumors

    The NET TEAM Bologna is dedicated to the study and cure of neuroendocrine tumors and rare, complex neoplasias, through an integrated approach involving various professional personnel with clinical as well as basic and translational research skills. The group’s combined skills make it possible to carry out highly complex projects.

  • Non-coding RNAs and cancer biomarkers

  • Otoneurosurgery

    This research group is dedicated to improvement and innovation in the diagnosis, prevention, and surgical treatment of diseases affecting the ear, temporal bone, and lateral skull base. The focus of the research is on minimally invasive surgical approaches—including the transcanal endoscopic technique—and endoscopic and endoscopic-assisted surgery for treating acoustic neuroma, training in otosurgery, and implementing robotic techniques for cochlear implants and middle ear surgery.

  • Genital Pathologies

    To improve current knowledge related to the diagnosis and treatment of the principal inflammatory pathologies of female and male genitals, with the purpose of improving the course of the disease, the prognosis, and ultimately the quality of life of the patient.

  • Divisional Program for Acute Leukemias and Myelodysplastic syndromes

    The research group’s objective is to develop innovative therapies through clinical, translational trials and observational and tissue studies.

  • PSYMED: General and clinical psychology in the healthcare domain

    The importance of psychological processes in health and healthcare pathways.

  • Diagnostic and Interventional Radiology

    The research group, guided by Prof. Rita Golfieri, is a reference point both nationally and internationally in the field of diagnostic and interventional radiology for cancer patients, minimally invasive surgery, and highly specialized medical imaging with the latest technologies (US, CT, and MR).

  • Research on lymph node metastases using molecular methods

    Use of the OSNA (One Step Nucleic Acid Amplification) method for the identification of metastatic cells within the lymph nodes.

  • RiPro: Ribosomal Proteins

    Ribosomal protein alterations in cancer and rare diseases

  • Nutrition as an anti-aging strategy

    How to age healthily? The goal of the research group is to study the pervasive role of nutrition as a non-pharmacological strategy for the prevention of accelerated aging and age-related diseases.

  • The Role of Tyrosine Kinase Membrane Receptors (RTK) in Tissue Homeostasis and Cancer Progression; mRNA biomarkers in colo-rectal cancer

    The research activities focus on studying the molecular mechanisms activated by RTKs, using confocal microscopy, CRISPR/CAS9, organoids, signalling analysis, an preclinical in vivo evaluations. In addition, we are investigating transcriptomics for validating RNA biomarkers.

  • Obstructive Sleep Apnea Syndrome - OSAS

    This research group is dedicated to the study of obstructive sleep apnea syndrome (OSAS), both in pediatric and adult patients. This is a life-threatening disease with a very high disease rate of 3–7% in the general population, with a number of anatomical abnormalities and neuromuscular dysfunctions that lead to repeated episodes of partial or complete airway obstruction during sleep. OSAS is associated with significant morbidity, such as cardiovascular and metabolic diseases, daytime hypersomnolence, neurocognitive deficits, and reduced quality of life. The role of the ENT head and neck surgeon is fundamental for classifying patients correctly and offering the most appropriate treatment options.

  • Protein synthesis and translational control in human pathology

    Our research group focuses on the study of the alterations in the cellular protein-synthetic mechanisms in tumors and rare diseases. The research results are applied to the diagnostic characterization and the identification of possible therapeutic targets.

  • Ocular surface and translational research in Ophthalmology

    The group is characterized by "bench and bedside" research on tissues and fluids of the eye-- in particular tears, conjunctival and corneal cells, secretions of the meibomian glands, cell cultures, and in vitro organ cultures, as well as in vivo research conducted in an outpatient area equipped with specific instrumentation for the ocular surface.

  • Embryonic development of the face

    Research into the factors involved in the embryonic development of the face, using the pathologies leading to congenital malformations (such as cleft lip and cleft palate) as a model.

  • Biology and Treatment of Chronic Myeloid Leukemia (CML)

    The CML research group has a clinical component, which is involved in the design and conduction of national and international clinical studies, and a laboratory component, which performs translational research.

  • Bacterial Toxins

    Molecular and Cellular Pathology of Bacterial Toxins and their role in Human Pathology; Molecular Pathology of ribosomes and translation

  • Allogenic transplantation of hematopeic stem cells and advanced cell-based therapies

    Clinical and biological research in the area of allogenic transplantation of hematopeic stem cells (GVHD, complications) and advanced cell-based therapies, such as CAR-T (predictive biomarkers for complications from cell-based therapies, new organizational models for the healthcare system)

  • Uropathology and molecular pathology of genitourinary tumours

    The group focuses on translational research with dignostic and predictive relapses in the field of genito-urinary tumors

  • Molecular Virology

    The engineering and preclinical effectiveness of oncolytic herpes simplex viruses (HSV) retargeted to cancer-specific receptors, as a single therapy or in combination with CPI. The immunological characterization of samples of murine tumors treated with oncolytic viruses.

  • Cancer Cell Biology

    Our primary research activity is the study of the metabolic characteristics of cancer cells, with particular reference to glucose metabolism. The aim is to evaluate how the metabolic rate of cancer cells can affect their phenotype and response to pharmacological treatments.